Profhilo vs Polynucleotides: Which is Right for You?
The world of injectable skincare has evolved far beyond traditional dermal fillers. Today, the two most sought-after treatments for skin rejuvenation are Profhilo and Polynucleotides. While both improve skin quality, they work in fundamentally different ways.
What is Profhilo?
Profhilo is an ultra-pure, high-concentration Hyaluronic Acid (HA) injectable. It acts as an internal moisturizer rather than a filler. It spreads beneath the skin like honey, drawing in water to provide intense hydration while stimulating collagen and elastin production.
- Best for: Dull, dehydrated, or crepey skin.
- Results: A visible "glass skin" glow, increased plumpness, and improved elasticity.
- Protocol: Two sessions, spaced four weeks apart.
What are Polynucleotides?
Polynucleotides (often derived from salmon or trout DNA) are regenerative medicine. Unlike HA which hydrates, Polynucleotides work at a cellular level. They communicate with your fibroblasts (the cells that make collagen) to repair tissue damage, reduce inflammation, and thicken the skin over time.
- Best for: Dark under-eye circles, rosacea, acne scarring, and deep cellular aging.
- Results: Thicker, more resilient skin, reduced pigmentation, and structural repair.
- Protocol: Three to four sessions, spaced two to three weeks apart.
The Verdict: Which Should You Choose?
If your primary concern is dryness, dullness, and a lack of glow, Profhilo is your best option. It delivers rapid, highly visible hydration.
If your concern is dark circles, thinning skin, rosacea, or tissue damage, Polynucleotides are the superior choice. They don't offer an instant glow, but they provide profound, long-term cellular repair.
Many elite clinics now combine both treatments for ultimate skin rejuvenation. Explore our Treatments Guide to learn more, or find a specialist near you in our Clinic Directory.